Plant Biotechnology Lab

PAPERS

  • Jilong Zhao, Yunlong Ge, Keqing Liu, Yasuyo Yamaoka, Di Zhang, Zhanyou Chi, Mahinur Akkaya, and Fantao Kong. (2023). Overexpression of a MYB1 Transcription Factor Enhances Triacylglycerol and Starch Accumulation and Biomass Production in the Green Microalga Chlamydomonas reinhardtii. Journal of Agricultural and Food Chemistry. https://doi.org/10.1021/acs.jafc.3c05290
  • Je, S., Choi, B. Y., Kim, E., Kim, K., Lee, Y., and Yamaoka, Y. (2023). Sterol Biosynthesis Contributes to Brefeldin-A-Induced Endoplasmic Reticulum Stress Resistance in Chlamydomonas reinhardtii. Plant And Cell Physiology, pcad131. https://doi.org/10.1093/pcp/pcad131
  • Je, S., Lee, Y., and Yamaoka, Y. (2023). Effect of common ER stress-inducing drugs on the growth and lipid phenotypes of Chlamydomonas and Arabidopsis. Plant Cell Physiol. https://doi.org/10.1093/pcp/pcac154
  • Chen, R., Yamaoka, Y., Feng, Y., Chi, Z., Xue, S., and Kong, F. (2023). Co-Expression of Lipid Transporters Simultaneously Enhances Oil and Starch Accumulation in the Green Microalga Chlamydomonas reinhardtii under Nitrogen Starvation. Metabolites 13. https://doi.org/10.3390/metabo13010115
  • Yamaoka, Y. (2022). Reverse to Forward Genetic Screen Spots the C-terminus of Plastidial Desaturase FAD6. Plant Cell Physiol 63, 1177-1180. https://doi.org/10.1093/pcp/pcac119
  • Shin, S., Chairattanawat, C., Yamaoka, Y., Yang, Q., Lee, Y., and Hwang, J.U. (2022). Early seed development requires the A-type ATP-binding cassette protein ABCA10. Plant Physiol 189, 360-374. https://doi.org/10.1093/plphys/kiac062
  • Je, S., and Yamaoka, Y. (2022). Biotechnological Approaches for Biomass and Lipid Production Using Microalgae Chlorella and Its Future Perspectives. J Microbiol Biotechnol 32, 1-16. https://doi.org/10.4014/jmb.2209.09012
  • Choi, B.Y., Shim, D., Kong, F., Auroy, P., Lee, Y., Li-Beisson, Y., Lee, Y., and Yamaoka, Y. (2022). The Chlamydomonas transcription factor MYB1 mediates lipid accumulation under nitrogen depletion. New Phytol 235, 595-610. https://doi.org/10.1111/nph.18141
  • Choi, B.Y., Kim, H., Shim, D., Jang, S., Yamaoka, Y., Shin, S., Yamano, T., Kajikawa, M., Jin, E., Fukuzawa, H., and Lee, Y. (2022). The Chlamydomonas bZIP transcription factor BLZ8 confers oxidative stress tolerance by inducing the carbon-concentrating mechanism. Plant Cell 34, 910-926. https://doi.org/10.1093/plcell/koab293
  • Yamaoka, Y., Shin, S., Lee, Y., Ito, M., Lee, Y., and Nishida, I. (2021). Phosphatidylserine Is Required for the Normal Progression of Cell Plate Formation in Arabidopsis Root Meristems. Plant Cell Physiol 62, 1396-1408. https://doi.org/10.1093/pcp/pcab086
  • Lee, J., Yamaoka, Y., Kong, F., Cagnon, C., Beyly-Adriano, A., Jang, S., Gao, P., Kang, B.H., Li-Beisson, Y., and Lee, Y. (2020). The phosphatidylethanolamine-binding protein DTH1 mediates degradation of lipid droplets in Chlamydomonas reinhardtii. Proc Natl Acad Sci U S A 117, 23131-23139. https://doi.org/10.1073/pnas.2005600117
  • Lee, E.J., Kim, K.Y., Zhang, J., Yamaoka, Y., Gao, P., Kim, H., Hwang, J.U., Suh, M.C., Kang, B., and Lee, Y. (2020). Arabidopsis seedling establishment under waterlogging requires ABCG5-mediated formation of a dense cuticle layer. New Phytol. https://doi.org/10.1111/nph.16816
  • Kim, A., Chen, J., Khare, D., Jin, J.Y., Yamaoka, Y., Maeshima, M., Zhao, Y., Martinoia, E., Hwang, J.U., and Lee, Y. (2020). Non-intrinsic ATP-binding cassette proteins ABCI19, ABCI20 and ABCI21 modulate cytokinin response at the endoplasmic reticulum in Arabidopsis thaliana. Plant Cell Rep 39, 473-487. https://doi.org/10.1007/s00299-019-02503-0
  • Jung, Y., Kwon, S., Ham, S., Lee, D., Park, H.H., Yamaoka, Y., Jeong, D.E., Artan, M., Altintas, O., Park, S., Hwang, W., Lee, Y., Son, H.G., An, S.W.A., Kim, E.J.E., Seo, M., and Lee, S.V. (2020). Caenorhabditis elegans Lipin 1 moderates the lifespan-shortening effects of dietary glucose by maintaining omega-6 polyunsaturated fatty acids. Aging Cell 19, e13150. https://doi.org/10.1111/acel.13150
  • Yamaoka, Y., Shin, S., Choi, B.Y., Kim, H., Jang, S., Kajikawa, M., Yamano, T., Kong, F., Legeret, B., Fukuzawa, H., Li-Beisson, Y., and Lee, Y. (2019). The bZIP1 Transcription Factor Regulates Lipid Remodeling and Contributes to ER Stress Management in Chlamydomonas reinhardtii. Plant Cell 31, 1127-1140. https://doi.org/10.1105/tpc.18.00723
  • Lee, D., An, S.W.A., Jung, Y., Yamaoka, Y., Ryu, Y., Goh, G.Y.S., Beigi, A., Yang, J.S., Jung, G.Y., Ma, D.K., Ha, C.M., Taubert, S., Lee, Y., and Lee, S.V. (2019). MDT-15/MED15 permits longevity at low temperature via enhancing lipidostasis and proteostasis. PLoS Biol 17, e3000415. https://doi.org/10.1371/journal.pbio.3000415
  • Kong, F., Yamaoka, Y., Ohama, T., Lee, Y., and Li-Beisson, Y. (2019). Molecular Genetic Tools and Emerging Synthetic Biology Strategies to Increase Cellular Oil Content in Chlamydomonas reinhardtii. Plant Cell Physiol. https://doi.org/10.1093/pcp/pcz022
  • Yamaoka, Y., Choi, B.Y., Kim, H., Shin, S., Kim, Y., Jang, S., Song, W.Y., Cho, C.H., Yoon, H.S., Kohno, K., and Lee, Y. (2018). Identification and functional study of the endoplasmic reticulum stress sensor IRE1 in Chlamydomonas reinhardtii. Plant J 94, 91-104. https://doi.org/10.1111/tpj.13844
  • Yamaoka, Y., Achard, D., Jang, S., Legeret, B., Kamisuki, S., Ko, D., Schulz-Raffelt, M., Kim, Y., Song, W.Y., Nishida, I., Li-Beisson, Y., and Lee, Y. (2016). Identification of a Chlamydomonas plastidial 2-lysophosphatidic acid acyltransferase and its use to engineer microalgae with increased oil content. Plant Biotechnol J 14, 2158-2167. https://doi.org/10.1111/pbi.12572
  • Hwang, J.U., Song, W.Y., Hong, D., Ko, D., Yamaoka, Y., Jang, S., Yim, S., Lee, E., Khare, D., Kim, K., Palmgren, M., Yoon, H.S., Martinoia, E., and Lee, Y. (2016). Plant ABC Transporters Enable Many Unique Aspects of a Terrestrial Plant’s Lifestyle. Mol Plant 9, 338-355. https://doi.org/10.1016/j.molp.2016.02.003
  • Lee, D., Jeong, D.E., Son, H.G., Yamaoka, Y., Kim, H., Seo, K., Khan, A.A., Roh, T.Y., Moon, D.W., Lee, Y., and Lee, S.J. (2015). SREBP and MDT-15 protect C. elegans from glucose-induced accelerated aging by preventing accumulation of saturated fat. Genes Dev 29, 2490-2503. https://genesdev.cshlp.org/content/29/23/2490
  • Kim, H., Jang, S., Kim, S., Yamaoka, Y., Hong, D., Song, W.-Y., Nishida, I., Li-Beisson, Y., and Lee, Y. (2015). The small molecule fenpropimorph rapidly converts chloroplast membrane lipids to triacylglycerols in Chlamydomonas reinhardtii. Frontiers in microbiology 6. https://doi.org/10.3389/fmicb.2015.00054
  • Hayakawa, Y., Duan, Z., Yadake, M., Tsukano, J., Yamaoka, Y., Inatsugi, R., Fujiki, Y., Oikawa, A., Saito, K., and Nishida, I. (2015). Epigenetic floral homeotic mutation in pD991-AP3-derived T-DNA-tagged lines for CTP: Phosphorylcholine cytidylyltransferase (CCT) Genes: The homeotic mutation of the cct1-1 allele is enhanced by the cct2 allele and alleviated by CCT1 overexpression. Journal of Plant Biology 58, 183-192. https://doi.org/10.1007/s12374-014-0587-y
  • Choi, H., Ohyama, K., Kim, Y.-Y., Jin, J.-Y., Lee, S.B., Yamaoka, Y., Muranaka, T., Suh, M.C., Fujioka, S., and Lee, Y. (2014). The role of Arabidopsis ABCG9 and ABCG31 ATP binding cassette transporters in pollen fitness and the deposition of steryl glycosides on the pollen coat. The Plant Cell 26, 310-324. https://doi.org/10.1105/tpc.113.118935
  • Kim, S., Yamaoka, Y., Ono, H., Kim, H., Shim, D., Maeshima, M., Martinoia, E., Cahoon, E.B., Nishida, I., and Lee, Y. (2013). AtABCA9 transporter supplies fatty acids for lipid synthesis to the endoplasmic reticulum. Proceedings of the National Academy of Sciences 110, 773-778. https://doi.org/10.1073/pnas.1214159110
  • Kim, S., Kim, H., Ko, D., Yamaoka, Y., Otsuru, M., Kawai-Yamada, M., Ishikawa, T., Oh, H.M., Nishida, I., Li-Beisson, Y., and Lee, Y. (2013). Rapid induction of lipid droplets in Chlamydomonas reinhardtii and Chlorella vulgaris by Brefeldin A. PLoS One 8, e81978. https://doi.org/10.1371/journal.pone.0081978
  • Fujiki, Y., Kudo, K., Ono, H., Otsuru, M., Yamaoka, Y., Akita, M., and Nishida, I. (2013). Genetic disruption of CRC 12S globulin increases seed oil content and seed yield in Arabidopsis thaliana. Plant Biotechnology 30, 327-333.  https://doi.org/10.5511/plantbiotechnology.13.0305a
  • Yamaoka, Y., Yu, Y., Mizoi, J., Fujiki, Y., Saito, K., Nishijima, M., Lee, Y., and Nishida, I. (2011). PHOSPHATIDYLSERINE SYNTHASE1 is required for microspore development in Arabidopsis thaliana. The Plant Journal 67, 648-661. https://doi.org/10.1111/j.1365-313X.2011.04624.x
  • Inatsugi, R., Kawai, H., Yamaoka, Y., Yu, Y., Sekiguchi, A., Nakamura, M., and Nishida, I. (2009). Isozyme-specific modes of activation of CTP: phosphorylcholine cytidylyltransferase in Arabidopsis thaliana at low temperature. Plant and cell physiology 50, 1727-1735. https://doi.org/10.1093/pcp/pcp115

PATENTS (Application and Registration)

  • Sep 16 2011, Composition for increasing seed size or content of storage lipid in seed, comprising the ABC transporter protein-coding gene (PCT/KR2011/006826, PCT)

INDUSTRIAL TECHNOLOGY TRANSFER

  • PCT/KR2011/006826 to Bayer at 2011 (€ 45,000)

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